"Project Blueprint" involves eating the same two meals every day, a regimented exercise routine and a structured sleep schedule. But can it really slow or reverse the ageing process?
Tom Accart Lescarcelle's insight:
Discover now how this controversial American millionaire managed to reverse his aging thanks to epigenetics!
Honey bee populations worldwide are declining drastically, but a new study sheds light on how a transmissible RNAi pathway might be able to help honey bees become more resistant to pathogens and other threats.
Ageing has always been inevitable but fasting, epigenetic reprogramming and parabiosis are just some of the scientific techniques that seem to help people stay young. Might the Peter Pan dream become real?
00:00 - Can science turn back the clock? 01:01 - Centenarians 02:51 - What is ageing? 04:51 - Dietary restriction 06:00 - Roundworms 07:55 - Epigenetics 09:43 - Blood and guts 11:40 - Senolytics 12:38 - Metformin 13:51 - Anti-ageing treatments are coming
Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging. Thanks to LastPass for sponsoring this video. Click here to start using LastPass: https://ve42.co/VeLP
What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.
To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.
Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.
Special thanks to: Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To" Assistant Professor David Gold Noemie Sierra (for polyp images) Genepool Productions for telomere animations from Immortal: https://ve42.co/immortal Epigenetics animations (DNA, histones, methylation etc) courtesy of: http://wehi.tv Animation: Etsuko Uno Art and Technical Direction: Drew Berry Sound Design: Francois Tetaz & Emma Bortignon Scientific Consultation: Marnie Blewitt Courtesy of Walter and Eliza Hall Institute of Medical Research
Filming, editing and animation by Jonny Hyman and Derek Muller
A new mouse study by researchers at Northwestern Medicine offers hope as it demonstrates an epigenetics drug currently being used for blood cancers and rare sarcomas may halt the growth of bladder cancer by activating the immune system.
Tom Accart Lescarcelle's insight:
In this recent study, researchers at Northwestern Medicine have discovered that an epigenetic drug, tazemetostat, initially developed for blood cancers and rare sarcomas, shows promise in halting the growth of bladder cancer in mice. Unlike traditional tumor inhibition, this drug activates the immune system, marking a paradigm shift in treating one of the most common solid tumors. Lead author Joshua Meeks highlights the drug's unique mechanism and its potential to enhance survival in advanced bladder cancer. The study underscores the role of epigenetic therapy in bladder cancer, with tazemetostat now undergoing clinical trials for late-stage bladder cancer patients, offering a new avenue for effective treatment.
Bio-Synergy CEO Daniel Herman speaks about the role of nutrients, DNA and epigenetics in space exploration and how these concepts can be applied closer to home...
I will explain the social behaviour of—and between—autistic people and neurotypicals, using honey bees as an analogy. It will make sense soon, I promise!
merci de partager tes usages, et ces ressources canadiennes! Tu t'es inscrit à BSI à Toronto, c'est en ligne et gratuit. Bonne année 2024 en attendant le dragon
Autism is characterized by impairments in social communication and interaction and restricted and repetitive behaviors. In this video, I discuss the neuroscience of autism along with potential factors and mechanisms involved in the development of autism.
TRANSCRIPT:
Autism, also known as autism spectrum disorder, is characterized by symptoms that include impairments in social communication and interaction and restricted and repetitive behaviors. Although the neuroscience of autism is still poorly understood, autism is considered to be a complex developmental disorder that involves atypical brain organization starting early in development.
Individuals with autism often experience a period of unusually rapid brain growth in infancy and early childhood. This accelerated brain growth is linked to an atypical pattern of connectivity between brain regions. A number of studies report that alterations in brain circuitry involved with social interaction and attention can be detected well before the symptoms of autism begin to appear. At this point, however, it’s unclear how brain overgrowth and atypical connectivity might be linked to the occurrence of autism symptoms.
Research suggests that the risk of autism is strongly influenced by genetics, yet studies consistently report that environmental factors also play a large role. Although a number of potential environmental factors have been identified, the risk factors for autism are far from definitive, and it remains unclear which factors are responsible for causing an increase in autism risk, and which are associated in a non-causal way. The risk factors that are most strongly linked to autism are associated with the prenatal or perinatal period. Thus, it’s possible they might be responsible for disruptions to typical neural development, leading to symptoms of autism months or years later. How these risk factors might interfere with neural development is still uncertain, but hypotheses have suggested potential mechanisms such as epigenetic effects, inflammation, oxidative stress, or damage caused by oxygen deficiency. More work needs to be done, however, to fully elucidate the genetic and environmental risk factors for autism, as well as the mechanisms for the development of autism symptoms.
REFERENCES:
Lord C, Brugha TS, Charman T, Cusack J, Dumas G, Frazier T, Jones EJH, Jones RM, Pickles A, State MW, Taylor JL, Veenstra-VanderWeele J. Autism spectrum disorder. Nat Rev Dis Primers. 2020 Jan 16;6(1):5. doi: 10.1038/s41572-019-0138-4. PMID: 31949163.
Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J. Autism spectrum disorder. Lancet. 2018 Aug 11;392(10146):508-520. doi: 10.1016/S0140-6736(18)31129-2. Epub 2018 Aug 2. PMID: 30078460; PMCID: PMC7398158.
Modabbernia A, Velthorst E, Reichenberg A. Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol Autism. 2017 Mar 17;8:13. doi: 10.1186/s13229-017-0121-4. PMID: 28331572; PMCID: PMC5356236.
Muhle RA, Reed HE, Stratigos KA, Veenstra-VanderWeele J. The Emerging Clinical Neuroscience of Autism Spectrum Disorder: A Review. JAMA Psychiatry. 2018 May 1;75(5):514-523. doi: 10.1001/jamapsychiatry.2017.4685. PMID: 29590280.
Tom Accart Lescarcelle's insight:
Surprisingly again, epigenetic effects could play a role in the development of autism according to this source
This very interesting YouTube video features Nessa Carey, a distinguished British biologist with decades of research in molecular biology and biotechnology. The discussion centers around the often misunderstood field of epigenetics, shedding light on how DNA expression evolves throughout our lives. The exploration extends to gene editing and CRISPR, providing insights into their current state, potential applications in disease healing and ecological problem-solving, as well as the regulatory challenges they present. The conversation delves into the profound implications of gene editing for both humanity and the planet, offering a comprehensive overview of the cutting-edge developments in these scientific realms.
To get content containing either thought or leadership enter:
To get content containing both thought and leadership enter:
To get content containing the expression thought leadership enter:
You can enter several keywords and you can refine them whenever you want. Our suggestion engine uses more signals but entering a few keywords here will rapidly give you great content to curate.
Your new post is loading...
Scoop.it!
