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Scoop.it!
Single dose of century-old drug approved for sleeping sickness reverses autism-like symptoms in mice
In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old. 
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BigField GEG Tech's insight:
What is the real contibution of the genetic in autism? Is it possible to induce autism without genetic predisposition? Seemingly, we are not yet able to answer od these questions.
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The researchers have tested the effect of suramin, a well-known inhibitor of purinergic signaling that was used to treat trypanosomiasis or African sleeping sickness, a parasitic disease. They found that suramin blocked the extracellular signaling pathway used by ATP and other mitokines in a mouse model of autism spectrum disorder (ASD), ending the cell danger response and related inflammation. Cells subsequently began behaving normally and autism-like behaviors and metabolism in the mice were corrected.
http://geg-tech.com/