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Bioscience News - GEG Tech top picks
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BigField GEG Tech's insight:
A pair of mathematicians has introduced a new way of thinking about the incredible complexity of how these biological systems interact, which may help set the stage for better understanding of our bodies and other living things. 
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A multidisciplinary team of researchers gives birth to a unique method that enables instant, specific labeling of individual cells, Cell Labelling via Photobleaching (CLaP). This method will become a precious ally in a wide range of scientific research, with particular applications for genomics.
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A device developed by Massachusetts General Hospital investigators may bring rapid, accurate molecular diagnosis of tumors and other diseases to locations lacking the latest medical technology. In their report appearing in PNAS, the researchers describe a smartphone-based device that uses the kind of technology used to make holograms to collect detailed microscopic images for digital analysis of the molecular composition of cells and tissues.
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Video: Rick Groleau DNA repair is essential for cell vitality, cell survival and cancer prevention, yet cells’ ability to patch up damaged DNA declines with age for reasons not fully understood. Now, research led by scientists at Harvard Medical School reveals a critical step in a molecular chain of events that allows cells to mend their broken DNA. The findings, published March 24 in Science, offer a critical insight into how and why the body’s ability to fix DNA dwindles over time and point to a previously unknown role for the signaling molecule NAD as a key regulator of protein-to-protein interactions in DNA repair. NAD, identified a century ago, is already known for its role as a controller of cell-damaging oxidation.
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Scientists from the University of Washington recently reported a relatively simple method that would allow ordinary laboratory microscopes to illuminate many of these cellular structures quickly and efficiently. They did not modify microscopes to boost resolution. Instead, they used an approach to swell the tiny, complex structures within cells, bringing them within range of a microscope's existing resolving range.
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Living cells respond to threats in their environment. What if materials could do the same? Using a similar pressure-regulating mechanism to that found in cells, scientists created an artificial cell that responds to a sudden and possibly catastrophic change in its surroundings.
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A new device creates nanopores in adherent cell membranes, allowing researchers to deliver molecules directly into the cells during differentiation. "The ability to deliver molecules into adherent cells without disrupting differentiation is needed for biotechnology researchers to advance both fundamental knowledge and the state-of-the-art in stem cell research," one researcher notes.
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Johns Hopkins researchers report they have uncovered a mechanism in amoebae that rapidly changes the way cells migrate by resetting their sensitivity to the naturally occurring internal signaling events that drive such movement. The finding, described in a report published online March 28 in Nature Cell Biology, demonstrates that the migratory behavior of cells may be less “hard-wired” than previously thought, the researchers say, and advances the future possibility of finding ways to manipulate and control some deadly forms of cell migration, including cancer metastasis.