Using 3D electron microscopy, structural biologists from the University of Zurich succeeded in elucidating the architecture of the lamina of the cell nucleus at molecular resolution for the first time.
Scientists from the University of Washington recently reported a relatively simple method that would allow ordinary laboratory microscopes to illuminate many of these cellular structures quickly and efficiently. They did not modify microscopes to boost resolution. Instead, they used an approach to swell the tiny, complex structures within cells, bringing them within range of a microscope's existing resolving range.
For the first time, biochemists from the University of Zurich have succeeded in elucidating the structure of the transportation channel inside the nuclear pores in high resolution using high-performance electron microscopes.
In this study, the authors combines intravital microscopy, microscopic X-ray computed tomography and three-dimensional electron microscopy to captured single tumor cells in the vasculature of the cerebral cortex and in subcutaneous tumors, providing unique insights into metastatic events. The versatility of this workflow allows envisioning broad applications in various fields of biological research such as cancer or developmental biology.
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Using 3D electron microscopy, structural biologists from the University of Zurich succeeded in elucidating the architecture of the lamina of the cell nucleus at molecular resolution for the first time.