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Genetic Engineering Publications - GEG Tech top picks
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The authors describe here three distinct Class 2 CRISPR-Cas systems. The effectors of two of the identified systems, C2c1 and C2c3, contain RuvC-like endonuclease domains distantly related to Cpf1 while the third system, C2c2, contains an effector with two predicted HEPN RNase domains. Comparative analysis indicates that Class 2 CRISPR-Cas systems evolved on multiple occasions through recombination of Class 1 adaptation modules with effector proteins acquired from distinct mobile elements. 
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The discovery of two distinct endonuclease activities in the C2c2 protein explains how template RNAs are processed in type VI CRISPR systems and enables the development of a sensitive RNA detection system.