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Genetic Engineering Publications - GEG Tech top picks
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BigField GEG Tech's insight:
In this issue, the authors describe CRISPR-Display (CRISP-Disp), a new approach that deploys RNA-based synthetic devices and lncRNAs to a genomic locus via Cas9-mediated targeting, as both a flexible tool for practical applications and a way to better understand lncRNA function. CRISP-Disp enables a wide range of potential applications, and they demonstrate both orthogonal multiplexing of transcriptional activation at multiple loci and live-cell imaging of a genomic locus using a fluorophore-binding RNA aptamer. 
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In a recent issue of Nature Methods, Shechner et al. (2015) reported the development of CRISPR Display (CRISP-Disp), which is a sophisticated, flexible, modular, and multiplexable platform for targeting different types of non-coding RNAs (ncRNAs) to genomic loci. CRISP-Disp will facilitate synthetic-biology applications and enable the elucidation of ncRNA functions.
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