The authors describe an efficient method to induce specific chromosomal rearrangements in vivo using viral-mediated delivery of the CRISPR/Cas9 system to somatic cells of adult animals. They apply it to generate a mouse model of Eml4–Alk-driven lung cancer.
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The authors describe an efficient method to induce specific chromosomal rearrangements in vivo using viral-mediated delivery of the CRISPR/Cas9 system to somatic cells of adult animals. They apply it to generate a mouse model of Eml4–Alk-driven lung cancer.
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