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Genetic Engineering Publications - GEG Tech top picks
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In this study, the authors have used piggyBac transposon in human ES cells to show that DENND2C negatively regulates RHOA activity, which cooperates with NANOG to block differentiation. They demonstrated that RHOA associates with DNA and that DENND2C affects nuclear RHOA localization, activity, and DNA association. 
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In this study, the authors established a protocol for differentiating mouse and human pluripotent stem cells into muscle. Their strategy provides an attractive model to study the origin of the pathological defects associated with DMD.
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