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Genetic Engineering Publications - GEG Tech top picks
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BigField GEG Tech's insight:
Here, the authors discuss advantages and challenges of intracellular production strategies and describe emerging approaches based on the direct delivery of protein either by transfer of recombinant protein or by lentiviral protein transduction. With focus on adapting viruses for protein delivery, they describe the concept of ‘all-in-one’ lentiviral particles engineered to co-deliver effector proteins and donor sequences for DNA transposition or homologous recombination. 
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The ability to form new memories of invasion depends on the ability of a CRISPR to incorporate new spacers. The mechanistic basis for this acquisition from DNA is increasingly understood and has often been assumed to be the sole mode of CRISPR adaptation. Silas et al. describe an intriguing twist on bacterial adaptive immunity, identifying a subset of CRISPR systems with the remarkable ability to incorporate new spacers directly from RNA.