Genetic Engineering Publications - GEG Tech top picks

The authors show that activation of the TGFβ pathway in hPSC-derived chondrogenic progenitors promotes the efficient development of articular chondrocytes that can form stable cartilage tissue in vitro and in vivo. In contrast, chondrocytes specified by BMP4 signaling display characteristics of hypertrophy and give rise to cartilage tissues that initiate the endochondral ossification process in vivo.

www.geg-tech.com/Vectors

The scientists report a CRISPR/Cas9-based methodology for rapidly integrating a firefly luciferase gene in somatic cells under the control of endogenous promoter, using the TGFβ-responsive gene PAI-1. Using chemical and genetic regulators of TGFβ signalling, they show that it mimics the transcriptional regulation of endogenous PAI-1 expression.

www.geg-tech.com/Vectors