Genetic Engineering Publications - GEG Tech top picks
36.6K views | +1 today
Follow
Genetic Engineering Publications - GEG Tech top picks
Biology
Your new post is loading...
Your new post is loading...
Scooped by BigField GEG Tech
Scoop.it!

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells | Genetic Engineering Publications - GEG Tech top picks | Scoop.it
From www.nature.com - January 16, 2018 1:39 PM
Article
BigField GEG Tech's insight:
Here the authors describe a system that mimics natural antigen-presenting cells (APCs) and consists of a fluid lipid bilayer supported by mesoporous silica micro-rods. APC-ms support over fivefold greater expansion of restimulated CD19 CAR-T cells than Dynabeads, with similar efficacy in a xenograft lymphoma model.
more...
No comment yet.
Sign up to comment
Scooped by BigField GEG Tech
Scoop.it!

Sequential cancer mutations in cultured human intestinal stem cells - Nature

Sequential cancer mutations in cultured human intestinal stem cells - Nature | Genetic Engineering Publications - GEG Tech top picks | Scoop.it
From www.nature.com - April 30, 2015 10:10 AM
BigField GEG Tech's insight:

The authors utilize CRISPR/Cas9 technology for targeted gene modification of four of the most commonly mutated colorectal cancer genes (APC, P53, KRAS and SMAD4) in cultured human intestinal stem cells. Upon xenotransplantation into mice, quadruple mutants grow as tumours with features of invasive carcinoma. Finally, combined loss of APC and P53 is sufficient for the appearance of extensive aneuploidy, a hallmark of tumour progression.


www.geg-tech.com/Vectors

more...
No comment yet.
Sign up to comment
About Follow us Resources Terms Mobile Features
Facebook
X
LinkedIn