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Genetic Engineering Publications - GEG Tech top picks
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Genome editing of human ES/iPS cells has been limited by technical difficulties that result in a low efficiency of homologous recombination (HR) in human ES/iPS cells.
In this work, the authors demonstrated that RAD51 overexpression and valproic acid treatment enhanced biallelic-targeting efficiency in human ES/iPS cells regardless of the transcriptional activity of the targeted locus. Their findings would facilitate genome editing study using human ES/iPS cells.