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Genetic Engineering Publications - GEG Tech top picks
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BigField GEG Tech's insight:
In this study, the authors present a genetically encoded device (DNAi) based on CRISPR system. DNAi allows to degrade specific intracellular DNA with an inducible and targeted manner. When a plasmid is targeted, it is rapidly lost from a population, and when the genome is targeted, this results in rapid cell death. The DNAi device is non-toxic when carried in the genome, is stable for months and does not impart background activity until induced. 
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BigField GEG Tech's insight:
“Unexpected mutations” simply represent SNPs and indels shared in common by these mice prior to nuclease treatment. What is your opinion?
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UC Berkeley researchers have made CRISPR/cas9 system even more versatile by giving it an “on” switch, allowing users to keep the Cas9 gene editor turned off in all cells except its designated target.