Genetic Engineering Publications - GEG Tech top picks

Here the authors report a method for differentiating human pluripotent stem cells to inner ear organoids that harbor functional hair cells. Using a three-dimensional culture system, the authors modulate TGF, BMP, FGF, and WNT signaling to generate multiple otic-vesicle-like structures from a single stem-cell aggregate. Over 2 months, the vesicles develop into inner ear organoids with sensory epithelia that are innervated by sensory neurons. Their culture system should facilitate the study of human inner ear development and research on therapies for diseases of the inner ear.