Haploid cells are useful for studying gene functions because disruption of a single allele can cause loss-of-function phenotypes. The authors speak about the use of the CRISPR sytem in haploid ESCs to generate multiple knockouts and large deletions at high efficiency. In addition, genome-wide screening is facilitated by haploid cell lines containing gene knockout libraries.
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Haploid cells are useful for studying gene functions because disruption of a single allele can cause loss-of-function phenotypes. The authors speak about the use of the CRISPR sytem in haploid ESCs to generate multiple knockouts and large deletions at high efficiency. In addition, genome-wide screening is facilitated by haploid cell lines containing gene knockout libraries.
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