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Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated
symptoms, prolongs lifespan in progeroid mice, and improves tissue homeostasis in
older mice.
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Here, the scientists report that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging.