Genetic Engineering Publications - GEG Tech top picks

Here the scientists detected microsatellite instability (MSI) in 21 CRISPR/Cas9 mouse strains using a panel of 42 microsatellite loci which were selected from our previous studies. Surprisingly, MSI occurrence was common in CRISPR/Cas9 modified genome, and most of the strains (19/21, 90.5%) examined showed MSI.

Through analyzing the mutation of microsatellite loci, the authors of the study provide new insights into the genomic alterations of CRISPR/Cas9 models and it will help us for a better understanding of this powerful technology.