In this study, the authors report that chemical alterations to synthesized single guide RNAs (sgRNAs) enhance genome editing efficiency in human primary T cells and CD34+ hematopoietic stem and progenitor cells. This approach could accelerate a wide array of biotechnological and therapeutic applications of the CRISPR-Cas technology.
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In this study, the authors report that chemical alterations to synthesized single guide RNAs (sgRNAs) enhance genome editing efficiency in human primary T cells and CD34+ hematopoietic stem and progenitor cells. This approach could accelerate a wide array of biotechnological and therapeutic applications of the CRISPR-Cas technology.
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