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Scoop.it!
Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated 
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Scoop.it!
BigField GEG Tech's insight:
Here, the authors describe an efficient Cas 9 version (Cas9) fused to a dihydrofolate reductase (DHFR)-derived destabilization domain (DD) and used to control gene expression with addition of Trimethoprim (TPM). They successfully used dCas9 to replace OCT4 in human cell and demonstrate that cell differentiation can be induced.
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Here, the scientists report that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging.