Genetic Engineering Publications - GEG Tech top picks

A new study reports an extension of the CRISPR (clustered regularly interspaced short palindromic repeat) technology that enables the simultaneous, tunable and directional control of expression of multiple genes. At its most basic, this method allows switching on one set of genes while switching off another set to generate synthetic multigene transcriptional programmes that can be induced to, for example, 'rewire' cell fates or engineer metabolic pathways.

To achieve flexible locus-specific transcriptional programming at multiple genes simultaneously, the researchers took advantage of features inherent to RNA, such as its modularity and programmability: RNA has previously been shown to form scaffolds that link DNA binding through base pairing to protein recruitment and the assembly of functional protein complexes.

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