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Scoop.it!
For the first time, scientists have created from scratch self-assembling protein filaments built from identical protein subunits that snap together spontaneously to form long, helical, thread-like structures. 
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Scoop.it!
BigField GEG Tech's insight:
The authors developed a protein delivery system consisting in the assembly of pyridylthiourea-grafted polyethylenimine (πPEI) with affinity-purified His-tagged proteins pre-organized onto a nickel-immobilized polymeric guide. The whole system efficiently carried the green fluorescent protein, single-chain antibodies or caspase 3, into the cytosol of living cells. Transduction of the protease caspase 3 induced apoptosis in two cancer cell lines, demonstrating that this new protein delivery method could be used to interfere with cellular functions.
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This protein-design advance could lead to creatiing materials unlike any in nature and with a range of applications, from diagnostics to nano-electronics.
Published in Science
De novo design of self-assembling helical protein filaments