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Scoop.it!
Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated 
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Scoop.it!
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
BigField GEG Tech's insight:
Using a CRISPR genome editing strategy the authors deleted a super-enhancer (SE) around the Sox2 gene in mouse embryonic stem cells (ESCs). The analysis of transcriptional defects showed that the SE is responsible for over 90% of Sox2 expression, suggesting that the functional significance of this SE is to maintain the pluripotency transcription program in mouse ESCs.
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Here, the scientists report that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging.