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Scoop.it!
Cellular RNAs are edited with high specificity using engineered ADAR-recruiting RNAs. 
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Scoop.it!
BigField GEG Tech's insight:
The authors offer an overview of the state-of-the-art of this rapidly emerging field, from a comparative description of the principal vector designs, to a synopsis of some of the most exciting applications that were reported to date, including the use of viral CRISPR vectors for genome-wide loss-of-function screens, multiplexed gene editing or disease modeling in animals.
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Scoop.it!
BigField GEG Tech's insight:
Three studies in Science and Cell identify ∼2,000 essential genes in human cell lines using CRISPR-Cas9 and retroviral gene-trap genetic screens.
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In this article, the scientists present an approach, called leveraging endogenous ADAR for programmable editing of RNA (LEAPER), that employs short engineered ADAR-recruiting RNAs (arRNAs) to recruit native ADAR1 or ADAR2 enzymes to change a specific adenosine to inosine. They pave the way for a single-molecule system, LEAPER, enabling precise, efficient RNA editing with broad applicability for therapy and basic research.