Design, Science and Technology

In ‘Application of high resolution DLP stereolithography for fabrication of tricalcium phosphate scaffolds for bone regeneration,’ researchers examine how to make complex, stable scaffolds based on β-tricalcium. Typically, there are obstacles to finding materials and techniques suitable for creating structures capable of sustaining cell life.

 

The authors are aware of the necessities in tissue engineering: the material cannot be toxic, obviously, as that would cause further health issues in a patient, biodegradability is key, with the material being absorbed along with suitable bone growth, and porosity and density must be suitable too, balanced out with proper strength.

 

DLP 3D printing has proven successful for creating scaffolds due to comprehensive irradiation over the whole cross-section, and shorter processing times in comparison to other processes. The researchers focused on DLP 3D printing for this study, in relation to the use of calcium phosphate structures that are not only complex and high resolution but also strong. The team assessed both rectilinear grid structure and hexagonal geometries (at 50 and 75 percent porosity) for mechanical properties, with complete chemical analyses performed before and after bioprinting.

Via Dr. Stefan Gruenwald

University of Toronto researchers have developed a handheld 3D skin printer that deposits even layers of skin tissue to cover and heal deep wounds. The team believes it to be the first device that forms tissue in situ, depositing and setting in place, within two minutes or less.

 

The research, led by PhD student Navid Hakimi under the supervision of Associate Professor Axel Guenther of the Faculty of Applied Science & Engineering, and in collaboration with Dr. Marc Jeschke, director of the Ross Tilley Burn Centre at Sunnybrook Hospital and professor of immunology at the Faculty of Medicine, was recently published in the journal Lab on a Chip.

 

For patients with deep skin wounds, all three skin layers – the epidermis, dermis and hypodermis – may be heavily damaged. The current preferred treatment is called split-thickness skin grafting, where healthy donor skin is grafted onto the surface epidermis and part of the underlying dermis.

 

Split-thickness grafting on large wounds requires enough healthy donor skin to traverse all three layers, and sufficient graft skin is rarely available. This leaves a portion of the wounded area “ungrafted” or uncovered, leading to poor healing outcomes.

Via Dr. Stefan Gruenwald