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Highlights
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Olaparib monotherapy at clinical concentrations induces cell death in AML blasts.
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AML blasts express undetectable BRCA1 protein.
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PARP1 and γH2AX are biomarkers to identify the response of AML to olaparib.
Via Krishan Maggon
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Rescooped by Gilbert C FAURE from Cancer Pathways inhibitors Collection |
Scoop.it!
Via Krishan Maggon
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1852, Issue 3, March 2015, Pages 462–472
BRCA1, PARP1 and γH2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparibIsabella Faraonia, b, , , Mirco Compagnoneb, , Serena Lavorgnab, c, , Daniela Francesca Angelinid, , Maria Teresa Cencionid, , Eleonora Pirasd, , Paola Panettab, c, , Tiziana Ottoneb, c, , Susanna Dolcic, , Adriano Vendittic, , Grazia Graziania, 1, , Francesco Lo-Cocob, c, 1, doi:10.1016/j.bbadis.2014.12.001