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Hematology

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#acute myeloid leukaemia AML 2

#biomarkers 1

#BRCA1/BRCA2 mutations 1

#induction therapy 1

#Olaparib 1

#PARP 1 1

#PARP inhibitors 1

#PLoS One 1

Hematology

Diagnosis, Therapy, Follow-up

Curated by Gilbert C FAURE

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Rescooped by Gilbert C FAURE from Cancer Pathways inhibitors Collection

Scoop.it!

From www.sciencedirect.com - May 11, 2015 2:07 PM

Krishan Maggon 's curator insight, May 10, 2015 2:56 AM

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Volume 1852, Issue 3, March 2015, Pages 462–472

BRCA1, PARP1 and γH2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparibIsabella Faraonia, b, , , Mirco Compagnoneb, , Serena Lavorgnab, c, , Daniela Francesca Angelinid, , Maria Teresa Cencionid, , Eleonora Pirasd, , Paola Panettab, c, , Tiziana Ottoneb, c, , Susanna Dolcic, , Adriano Vendittic, , Grazia Graziania, 1, , Francesco Lo-Cocob, c, 1, doi:10.1016/j.bbadis.2014.12.001

Rescooped by Gilbert C FAURE from Cancer Pathways inhibitors Collection

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From journals.plos.org - April 22, 2015 12:28 PM

Krishan Maggon 's curator insight, April 19, 2015 3:03 AM

Citation: Cesano A, Willman CL, Kopecky KJ, Gayko U, Putta S, et al. (2015) Cell Signaling-Based Classifier Predicts Response to Induction Therapy in Elderly Patients with Acute Myeloid Leukemia. PLoS ONE 10(4): e0118485. doi:10.1371/journal.pone.0118485