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Monoclonal gammopathies are diagnosed by a triad of criteria including clinical symptoms of the disease, bone marrow analysis and clinical laboratory testing. Protein electrophoresis and immunofixation in serum and urine are the most common tests in clinical laboratory for diagnosis of monoclonal gammopathies. More recently, serum free light chain testing has become an important tool for diagnosis and prognosis of these conditions. The indications and limitation of these clinical laboratory tests are reviewed in this presentation.
