"Results showed that curcumin induces growth arrest and apoptosis in pancreatic cancer cell lines. Its effect was more obvious on the highly COX-2 expressing cell line..."
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Longevity science
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Live longer in good health and you will have a chance to extend your healthy life even further
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Curcumin C3 Reduct, Sabinsa’s new patented and clinically safe 95% tetrahydrocurcuminoids, is the result of recent research into metabolites of curcuminoids that have unraveled the role of tetrahydrocurcuminoids as not only the major metabolites but also pharmacologically superior than curcuminoids themselves. It is not the curcumin, but its metabolite, tetrahydrocurcumin (THC), which is responsible for its biological function in the body.
Ray and Terry's 's insight:
Our Curcumall product utilizes this patented form of curcumin extract. 
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The up regulation of gut mucosal cytokines such as tumor necrosis factor (TNF)-α and oxidative stress have been related to inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). This study investigated an immune-mediated model of colitis.
TNF-α injected intraperitonally to mice induced a dose-dependent recruitment of neutrophils into abdominal mesentery. The leukocytes influx induced by TNF-α (10 μg kg(-1) body weight) increased by 3 fold liver and colon damage scores. TNF-α-colitis was characterized by hemorrhagic edemas and crypt abscesses massively infiltrated by inflammatory cells, namely neutrophils. Moreover, TNF-α-toxicity resulted in liver steatosis and foci of necrosis infiltrated by Kupffer cells and neutrophils in parenchyma and around the centrilobular veins. The involvement of oxidative stress was evaluated using aminoguanidine (AG) as selective inhibitor of inducible NO synthase (iNOS) and curcumin (Cur), the polyphenolic antioxidant of turmeric (Curcuma longa L.).
TNF-α-toxicity led to significant increase in myeloperoxidase (MPO, an index of neutrophils infiltration), nitrites (stable nitric oxide metabolites) and malondialdehyde (MDA, a marker of lipid peroxides) levels and cell apoptosis in liver and colon. AG and Cur treatments significantly attenuated the hallmarks of oxidative stress, neutrophils influx and ROS-related cellular and histological damages, in TNF-α-treated mice.
Taken together, our results provide insights into the role of phagocytes-derived oxidants in TNF-α-colitis in mice. Cur and AG, by inhibiting neutrophils priming and iNOsynthase could be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response.
REFERENCE: Int Immunopharmacol. 2012 Jan;12(1):302-11. Epub 2011 Oct 29. Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-α-induced oxidative stress, colitis and hepatotoxicity in mice. Mouzaoui S, Rahim I, Djerdjouri B.
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Daily supplements of curcumin may benefit cardiovascular health to the same extent as exercise for postmenopausal women, says new data from a clinical trial from Japan.
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Curcumin is a bioactive phytochemical with well-known antioxidant, anti-inflammatory, and cardioprotective properties. The present study investigated the hypolipidemic activity of curcumin in obese individuals.
The findings of the present study indicated that curcuminoid supplementation (1 g/day for 30 days) leads to a significant reduction in serum triglycerides concentrations but do not have a significant influence on other lipid profile parameters as well as body mass index and body fat.
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Researchers, whose results were published in the journal Diabetes Care, found that over nine months, a daily dose of curcumin seemed to prevent new cases of diabetes among people with so-called prediabetes - abnormally high blood sugar levels that may progress to full-blown type 2 diabetes.
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Curcumin (extracted from the spice turmeric) is currently one of the most studied natural remedies.
A recent controlled study, published in the American Journal of Cardiology involved administering curcumin (or sugar pills) to bypass patients.
Those given curcumin pills had significantly lower levels of inflammation and oxidative stress indicators, as well as a 65% reduced risk of heart attack following the bypass surgery.
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Daily supplements of curcumin – the natural pigment that gives the spice turmeric its yellow color – may support healthy aging, with two new studies indicating benefits for arterial aging and cognition.
Ray and Terry's 's insight:
We carry a unique formula that uses a patented extract of curcumin and specialized extraction process for maximum bioavailability.
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Lab experiments and preliminary clinical studies indicate that curcuminoids support immune and brain health in uniquely powerful ways. And earlier this month, the authors of a review paper painted this positive picture of the substantial clinical evidence on curcumin:“Extensive clinical trials over the past quarter century have addressed the … efficacy of [curcumin and] promising effects have been observed in patients with various pro-inflammatory diseases including cancer, cardiovascular disease, arthritis … [and more than 25 others]. (Gupta SC et al. 2013).
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Promising new research has demonstrated once again that the ingredient curcumin, which is the principal curcuminoid of the widely used Indian spice turmeric, a member of the ginger family, is a major cancer fighter, this time proving effective against esophageal cancer.
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Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin.
In this small study, absorbable low doses of curcumin were seen to produce positive effects in healthy middle aged people. The results of the small study indicate that curcumin helps to protect health heart, brain, and immune system function.
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This study found a possible glucose-lowering effect of curcuminoids in type 2 diabetes.
Curcuminoids are found in turmeric, the orange spice often used in Indian cuisine.
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"Curcumin is a principal compound of turmeric, commonly used to treat tumors and other diseases. However, its anti-cancer activity in human acute monocytic leukemia THP-1 cells is not clear."
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Curcumin features a lot in research studies. Men with prostate concerns could look into adding curcumin to their diet. Curcumin is an active ingredient of the spice turmeric.