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Scientists discover why a specific cancer drug is so effective | KurzweilAI

Scientists discover why a specific cancer drug is so effective | KurzweilAI | Longevity science | Scoop.it

Scientists from the Manchester Collaborative Center for Inflammation Research (MCCIR) have discovered why a particular cancer drug is so effective at killing cells. Their findings could be used to aid the design of future cancer treatments.

Professor Daniel Davis and his team used high quality video imaging to investigate why the drug rituximab is so effective at killing cancerous B cells. It is widely used in the treatment of B cell malignancies, such as lymphoma and leukaemia — as well as in autoimmune diseases like rheumatoid arthritis.

 

 

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New Biomarker May Allow Earlier Diagnosis of Mesothelioma

"Researchers have shown that the protein fibulin-3 may be able to distinguish patients with mesothelioma from people with similar conditions and from healthy individuals. Although preliminary, the results suggest that this protein may be a promising new biomarker for diagnosing the disease and possibly informing prognosis. The study was published October 11 in the New England Journal of Medicine.

 

Pleural mesothelioma, a disease of the tissue that lines the chest cavity and covers the lungs (the pleura), is an aggressive cancer often associated with asbestos exposure. Patients diagnosed with this disease have a median survival of 1 year.

 

Diagnosing mesothelioma early, when treatment may be most effective, is difficult because of its long latency period and the lack of reliable methods to detect the disease in its early stages. A protein called soluble mesothelin-related protein is the best-studied biomarker for mesothelioma, but the test for it has low sensitivity, meaning that it fails to detect mesothelioma in some people who have the disease.."


Via Brian Shields
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First drug made in genetically-engineered plants cleared to enter the market

First drug made in genetically-engineered plants cleared to enter the market | Longevity science | Scoop.it

"Approval of a ‘biologic’ manufactured in plant cells may pave the way for similar products.

 

Drugs that are based on large biological molecules — known as biologics — have been produced inside genetically engineered animal cells, yeast and bacteria for more than two decades."

 

 


Via Dr. Stefan Gruenwald
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Engineered artificial human livers for drug testing and discovery | KurzweilAI

Engineered artificial human livers for drug testing and discovery | KurzweilAI | Longevity science | Scoop.it

Institute of Bioengineering and Nanotechnology (IBN) researchers have engineered an artificial human liver that mimics the natural tissue environment closely.

 

The development makes it possible for companies to predict the toxicity of new drugs earlier, potentially speeding up the drug development process and reducing the cost of manufacturing

 

 

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First Stem Cell-Based Therapy Gets Approved – In Canada | Singularity Hub

First Stem Cell-Based Therapy Gets Approved – In Canada | Singularity Hub | Longevity science | Scoop.it

A medical treatment that uses stem cells derived from bone marrow has just been approved in Canada.

 

The drug, Prochymal, has already been used to treat children for a type of immune disease arising during bone marrow transplantation.

 

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Poster: Mining PubMed for Biomarker-Disease Associations to Guide Discovery | Walter Jessen Discovery New Media

Poster: Mining PubMed for Biomarker-Disease Associations to Guide Discovery | Walter Jessen Discovery New Media | Longevity science | Scoop.it

This article highlights the power of the internet to help drive future biomarker research and drug discovery...Incredible innovation using very low cost tools


Via Brian Shields
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