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A way to stimulate the brain’s natural defense mechanisms in people with Alzheimer’s disease has been discovered by researchers at Université Laval, CHU de Québec and pharmaceutical firm GlaxoSmithKline (GSK): a molecule known as MPL (monophosphoryl lipid A) that stimulates the activity of the brain’s immune cells.
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In neurodegenerative diseases, the choroid plexus and CPECs age prematurely, resulting in reduced CSF formation and decreased ability to flush out the plaque-forming proteins that are a hallmark of Alzheimer’s.
Transplant studies have provided proof of concept for CPEC-based therapies. However, such therapies have been hindered by the inability to expand or generate CPECs in culture.
“Our method is promising, because for the first time we can use stem cells to create large amounts of these epithelial cells, which could be utilized in different ways to treat neurodegenerative diseases,” said Monuki, an associate professor of pathology & laboratory medicine and developmental & cell biology at UCI.
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Researchers compared vitamin E levels in Alzheimer's, mild cognitive impairment, and cognitively normal subjects.
Individuals with cognitive impairment or Alzheimer's had lower blood levels of vitamin E.
The study concluded that both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD.
Neurobiol Aging. 2012 Oct;33(10):2282-90. Epub 2011 Dec 20.
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By turning off an immune system transmitter in mice with an Alzheimer’s-like condition, scientists have been able to greatly reduce the accumulation of an abnormal protein known as amyloid-ß in the animals’ brains.
Previous studies have shown that the protein plays a central role in Alzheimer’s disease. It is hoped that the research may ultimately point the way towards a method of preventing or treating the disease in humans.
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Mayo Clinic study in seniors finds that diets high in sugars and starches promote brain fog and dementia.
Correlations between carb intake and brain fog included: *Those with the highest carbohydrate intake relative to total fat and protein intake were 3.6 times likelier to develop MCI.
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