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Front Immunol. 2019 Jan 22;10:16. doi: 10.3389/fimmu.2019.00016. eCollection 2019.Review... 
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When activated by viral infection, plasmacytoid dendritic cells (pDCs) play a primary role in the immune response through secretion of IFN-α. Lactococcus lactis subsp. Via Krishan Maggon
Krishan Maggon 's curator insight,
March 8, 2015 12:57 AM
Citation: Jounai K, Sugimura T, Ohshio K, Fujiwara D (2015) Oral Administration ofLactococcus lactis Subsp. lactis JCM5805 Enhances Lung Immune Response Resulting in Protection from Murine Parainfluenza Virus Infection. PLoS ONE 10(3): e0119055. doi:10.1371/journal.pone.0119055 |
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J Crohns Colitis. 2018 Nov 12. doi: 10.1093/ecco-jcc/jjy186.[Epub ahead of print]...
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Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26. These cytokines are all members of the larger IL-10 family, but have been grouped together to form the IL-20 subfamily based on their usage of common receptor subunits and similarities in their target-cell profiles and biological functions. Members of the IL-20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. In this Review, we describe the cellular sources and targets of the IL-20 subfamily cytokines, and we detail how their expression is regulated. Much of our understanding of the unique biology of this group of cytokines is still based on IL-22, which is the most studied member of the IL-20 subfamily. Nevertheless, we attempt a broader discussion of the emerging functions of IL-20 subfamily cytokines in host defence, inflammatory diseases, cancer and metabolism. Via Krishan Maggon
Gilbert C FAURE's insight:
nice review
Krishan Maggon 's curator insight,
December 14, 2014 2:22 AM
NATURE REVIEWS IMMUNOLOGY | REVIEW The IL-20 subfamily of cytokines — from host defence to tissue homeostasisSascha Rutz,Xiaoting Wang& Wenjun OuyangAffiliationsCorresponding authorNature Reviews Immunology 14, 783–795 (2014) doi:10.1038/nri3766Published online 25 November 2014 |
