Covering: up to 2016"
Dictazoles and sceptrins are singular metabolites of marine origin. The present dichotomic case study provides a comprehensive perspective on these cyclobutane-centered alkaloids and their respective families. Indeed, their upstream and downstream chemistry are both treated herein. Relevant isolation reports and bio-inspired total syntheses are used to decipher the currently admitted biosynthetic hypotheses as well as the emergence of diversity in the two series. This review proposes a transversal vision of the topic, where most aspects of natural product chemistry have a critical importance.
Mehdi A. Beniddir,a Laurent Evanno,a Delphine Joseph,a Adam Skiredj*a and Erwan Poupon*a
A deep-sea dive into the ecology and chemistry of surprising cyclobutanes from marine invertebrates.