Powerful changes are impacting traditional systems of research publication, academic credit, research quality assessment, and the meaning of “publication.” At the same time, traditional publishing models continue to shape how scholars produce and exchange knowledge. Understanding the scholarly communication system and its balance between transformation and continuity is a key goal for science and technology studies, as publishing practices affect scholars and scientists across all fields and levels. These changes also frame the policies of administrators evaluating and funding them, and of libraries confronting new technologies. The increasing scale and interdisciplinary nature of collaborations, as well as the growing reliance on cyberinfrastructures for producing and disseminating research, are central transformations that require a critical, theoretically oriented approach that encompasses the significance of these trends beyond communication.