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Scoop.it!
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits... Via Alfredo Corell 
Alfredo Corell's curator insight,
January 10, 2014 11:46 AM
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The pathogenesis of systemic lupus erythematosus—an update Jinyoung Choi1, *,Sang Taek Kim1, *,Joe Craft1, 2, 1 Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States2 Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, United States http://dx.doi.org/10.1016/j.coi.2012.10.004,
Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.
The pathogenesis of systemic lupus erythematosus—an update [Current Opinion in Immunology—an update] http://t.co/gKMERgRK... Via Alfredo Corell
Gilbert C FAURE's comment,
August 17, 2013 11:26 AM
november 2012, a synthetic review of uptodate hypothesis
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Gilbert C FAURE's insight:
rheumatoid lung is histologicaly frequent according to some autopsy studies but seldomly clinically diagnosed already 4 pages of scoops related to rheumatoid arthritis http://www.scoop.it/t/rheumatology-rhumatologie?q=rheumatoid+art
Alfredo Corell's curator insight,
December 15, 2013 8:27 AM
Autoimmunity Reviews
Volume 12, Issue 11, September 2013, Pages 1076–1084 Benedetta Marigliano, Alessandra Soriano, Domenico Margiotta, Marta Vadacca, Antonella AfeltraAbstract The lungs are frequently involved in Connective Tissue Diseases (CTDs). Interstitial lung disease (ILD) is one of the most common pleuropulmonary manifestations that affects prognosis significantly. In practice, rheumatologists and other physicians tend to underestimate the impact of CTD-ILDs and diagnose respiratory impairment when it has reached an irreversible fibrotic stage. Early investigation, through clinical evidence, imaging and – in certain cases – lung biopsy, is therefore warranted in order to detect a possible ILD at a reversible initial inflammatory stage. In this review, we focus on lung injury during CTDs, with particular attention to ILDs, and examine their prevalence, clinical manifestations and histological patterns, as well as therapeutic approaches and known complications till date. Although several therapeutic agents have been approved, the best treatment is still not certain and additional trials are required, which demand more knowledge of pulmonary involvement in CTDs. Our central aim is therefore to document the impact that lung damage has on CTDs. We will mainly focus on Rheumatoid Arthritis (RA), which – unlike other rheumatic disorders – resembles Idiopathic Pulmonary Fibrosis (IPF) in numerous aspects.
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