Daily Magazine

Multitasking is an essential skill in the era of email, text messages, Facebook and Twitter. But, argues neuroscientist Daniel J Levitin, it’s actually making us less efficient

You can't do science without data, and a team at Berkeley has proposed a method to get a lot more data about the brain. All they need to do is sprinkle your brain with tiny dust-like sensors.

How is our consciousness connected to the world?
Explore the unconscious functions of the brain with visual illusions and mysterious perceptual phenomena.

Have you lost your house keys recently? If so, you probably applied a spot of logical thinking. You looked first in the most obvious places – bags and pockets – and then mentally retraced your steps to the point when you last used them.

Researchers looking at child development often use search-and-find tasks to look at the ways in which children apply what they are learning about the physical world. Tests carried out on toddlers reveal that something quite remarkable happens in child development between the ages of two and five – a stage identified by both educationalists and neuroscientists as critical to the capacity for learning.

Dr Sara Baker is a researcher into early childhood at the Faculty of Education. She is interested in the role of the brain’s prefrontal lobe in how young children learn to adapt their understanding to an ever-shifting environment. Many of her studies chart changes in children’s ways of thinking about the world. She uses longitudinal designs to examine the shape of individual children’s learning curves month by month.

Research by Baker and colleagues is contributing to an understanding of the acquisition of skills essential to learning. She explains: “The brain’s frontal lobe is one of the four major divisions of the cerebral cortex. It regulates decision-making, problem-solving and behaviour. We call these functions executive skills – they are at the root of the cognitive differences between humans and other animals. My executive functions enable me to resist a slice of cake when I know I’m soon having dinner.”

How do you want to be remembered? As Simon Parkin discovers, we may eventually be able to preserve our entire minds for generations to come – would you?

It is now possible to map the activity of nearly all the neurons in a vertebrate brain at cellular resolution. What does this mean for neuroscience research and projects like the Brain Activity Map proposal?

In a recent publication, Misha Ahrens and Philipp Keller from the HHMI’s Janelia Farm Research Campus used high-speed light sheet microscopy to image the activity of 80% of the neurons in the brain of a fish larva at speeds of a whole brain every 1.3 seconds. This represents—to our knowledge—the first technology that achieves whole brain imaging of a vertebrate brain at cellular resolution with speeds that approximate neural activity patterns and behavior.

In an Article that just went live in Nature Methods, Misha Ahrens and Philipp Keller from HHMI’s Janelia Farm Research Campus used high-speed light sheet microscopy to image the activity of 80% of the neurons in the brain of a fish larva at speeds of a whole brain every 1.3 seconds. This represents—to our knowledge—the first technology that achieves whole brain imaging of a vertebrate brain at cellular resolution with speeds that approximate neural activity patterns and behavior.

Interestingly, the paper comes out at a time when much is being discussed and written about mapping brain activity at the cellular level. This is one of the main proposals of the Brain Activity Map—a project that is being discussed at the White House and could be NIH’s next ‘big science’ project for the next 10-15 years. [Just for clarity, the authors of this work are not formally associated with the BAM proposal].

The details of BAM’s exact goals and a clear roadmap and timeline to achieve them have yet to be presented, but from what its proponents have described in a recent Science paper the main aspiration of the project is to improve our understanding of how whole neuronal circuits work at the cellular level. The project seeks to monitor the activity of whole circuits as well as manipulate them to study their functional role. To reach these goals, first and foremost one must have technology capable of measuring the activity of individual neurons throughout the entire brain in a way that can discriminate individual circuits. The most obvious way to do this is by imaging the activity as it is occurring.

With improvements in the speed and resolution of existing microscopy setups and in the probes for monitoring activity, exhaustive imaging of neuronal function across a small transparent organism was bound to be possible—as this study has now shown.

The study has also made interesting discoveries. The authors saw correlated activity patterns measured at the cellular level that spanned large areas of the brain—pointing to the existence of broadly distributed functional circuits. The next steps will be to determine the causal role that these circuits play in behavior—something that will require improvements in the methods for 3D optogenetics. Obtaining the detailed anatomical map of these circuits will also be key to understand the brain’s organization at its deepest level.