Virus World
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Virus World
Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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Limiting Indoor Capacity Can Reduce Coronavirus Infections, Study Shows - The New York Times

Limiting Indoor Capacity Can Reduce Coronavirus Infections, Study Shows - The New York Times | Virus World | Scoop.it

Research using cellphone data in 10 U.S. cities last spring could help influence officials’ decisions on new restrictions as cases resurge around the country. Restaurants, gyms, cafes and other crowded indoor venues accounted for some 8 in 10 new infections in the early months of the U.S. coronavirus epidemic, according to a new analysis that could help officials around the world now considering curfews, partial lockdowns and other measures in response to renewed outbreaks. The study, which used cellphone mobility data from 10 U.S. cities from March to May, also provides an explanation for why many low-income neighborhoods were hardest hit. The public venues in those communities were more crowded than in more affluent ones, and residents were more mobile on average, likely because of work demands, the authors said in the research published in the journal Nature on Tuesday. The data came from the metro areas of Atlanta, Chicago, Dallas, Houston, Los Angeles, Miami, New York, Philadelphia, San Francisco and Washington, D.C. Infectious disease models had provided similar estimates of the risk posed by crowded indoor spaces, going back to February; all such models are subject to uncertainties, due largely to unforeseen changes in community behavior. The new analysis provides more precise estimates for how much each kind of venue contributed to urban outbreaks, by tracking hourly movements and taking into account the reductions in mobility from lockdown restrictions or other changes that occurred during those first crucial months. It did not model infection in schools or office workplaces.

 

“Restaurants were by far the riskiest places, about four times riskier than gyms and coffee shops, followed by hotels” in terms of new infections, said Jure Leskovec, a computer scientist at Stanford University and senior author of the new report, in a conference call with reporters. The study was a collaboration between scientists at Stanford, Northwestern University, Microsoft Research and the Chan Zuckerberg Biohub. Public officials across Europe and in parts of the United States, including Gov. Phil Murphy of New Jersey, have begun to institute partial closures of restaurants and bars, or limited indoor hours, as new infections have surged in recent weeks. In New York City, a spike in virus cases threatens the city’s recovery and could mean “a lot more restrictions,” Mayor Bill de Blasio said on Monday. These measures are especially important in lower income areas, the new study suggests. Infections exploded in many such communities last spring, and the new model provides one likely explanation: Local venues tend to be more crowded than elsewhere.

 

The researchers looked closely at grocery stores, to understand differences between high and low income communities. In eight of the ten cities, transmission rates were twice as high in low as in higher income areas. The mobility data pointed at one reason: Grocers in low-income neighborhoods had almost 60 percent more people per square foot; shoppers tended to stay there longer as well. And residents are apparently less able to shelter at home. “We think a big reason for that is that essential workers had to be on the job, they weren’t working from home,” said Serina Chang, a co-author also at Stanford. In the analysis, the research team mapped the hourly mobility of some 98 million people to and from indoor public spaces, like grocery stores, churches, hotels and bars. It calculated the traffic to each venue over the course of a day, how long people stayed on average, and the place’s square footage. Given a background infection rate, the researchers then ran the model forward — “hit play,” said Dr. Chang, and watched how infections spread and where, using standard infectious disease assumptions....

 

Study cited published in Nature (Nov. 10, 2020):

https://doi.org/10.1038/s41586-020-2923-3

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Evidence for Probable Aerosol Transmission of SARS-CoV-2 in a Poorly Ventilated Restaurant

Evidence for Probable Aerosol Transmission of SARS-CoV-2 in a Poorly Ventilated Restaurant | Virus World | Scoop.it

The role of aerosols in the transmission of SARS-CoV-2 remains debated. We analysed an outbreak involving three non-associated families in Restaurant X in Guangzhou, China, and assessed the possibility of aerosol transmission of SARS-CoV-2 and characterize the associated environmental conditions.

 

We collected epidemiological data, obtained a video record and a patron seating arrangement from the restaurant, and measured the dispersion of a warm tracer gas as a surrogate for exhaled droplets from the suspected index patient. Computer simulations were performed to simulate the spread of fine exhaled droplets. We compared the in-room location of subsequently infected cases and spread of the simulated virus-laden aerosol tracer. The ventilation rate was measured using the tracer decay method.

 

Three families (A, B, C), 10 members of which were subsequently found to have been infected with SARS-CoV-2 at this time, or previously, ate lunch at Restaurant X on Chinese New Year’s Eve (January 24, 2020) at three neighboring tables. Subsequently, three members of family B and two members of family C became infected with SARS-CoV-2, whereas none of the waiters or 68 patrons at the remaining 15 tables became infected. During this occasion, the ventilation rate was 0.75–1.04 L/s per person. No close contact or fomite contact was observed, aside from back-to-back sitting by some patrons. Our results show that the infection distribution is consistent with a spread pattern representative of exhaled virus-laden aerosols.

 

Aerosol transmission of SARS-CoV-2 due to poor ventilation may explain the community spread of COVID-19.

 

Preprint available at medRxiv (April 22, 2020):

https://doi.org/10.1101/2020.04.16.20067728

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