Virus World
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Virus World
Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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Scientists Identify Interferon-gamma as Potential SARS-CoV-2 Antiviral | NIH: National Institute of Allergy and Infectious Diseases

Scientists Identify Interferon-gamma as Potential SARS-CoV-2 Antiviral | NIH: National Institute of Allergy and Infectious Diseases | Virus World | Scoop.it

Conditioning the lungs with interferon-gamma, a natural immune system protein (cytokine) best known for fighting bacterial infections, appears to be a strong antiviral for SARS-CoV-2, according to National Institutes of Health scientists and colleagues. Their new study, published in Nature Communications, shows in two different mouse models that when a bacterial infection triggers the release of interferon-gamma in the lungs, those animals subsequently are protected from infection by SARS-CoV-2, the virus that causes COVID-19. The investigators further report that using recombinant interferon-gamma in the nose of study mice at the time of viral exposure substantially reduces SARS-CoV-2 infection and COVID disease....

 

Published in Nature Communications (Dec. 2023):

https://doi.org/10.1038/s41467-023-43447-0 

 

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Self-Healing Bacteriophage Hydrogel to Target Infections

Self-Healing Bacteriophage Hydrogel to Target Infections | Virus World | Scoop.it

Antibiotics are the predominant tool when fighting bacterial infections, but bacteriophages could potentially be a lot more effective.Bacteriophages are  viruses that attack bacteria and because they avoid injuring human cells they are a promising therapeutic tool, if used correctly. Moreover, they can be used alongside antibiotics, since the two don’t affect each other.

 

At McMaster University in Canada researchers have developed a hydrogel loaded with an enormous amount of bacteriophage viruses that can overwhelm any bacterial defenses. Because the hydrogel has such a high concentration of bacteriophages, they end up joining together to create a self-healing material that reassembles after being cut. 

 

One millimeter of the gel holds over 300 trillion of the bacteriophage viruses, and if these are made to target specific bacterial infections, or even cancer through DNA modification, the gel may have impressive therapeutic effects. 

 

Here’s a video from McMaster University with the researchers that invented the new gel: 

https://youtu.be/lhIC-H7qzSw

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