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Chinese virologists have shed light on the mechanism of action of Naproxen, a non-steroidal anti-inflammatory drug commonly used to treat pain derived from arthritis, gout and many other conditions. The antiviral activity of naproxen was originally discovered in 2013. Now scientists have shown that naproxen effectively protects mice against influenza A and B virus infection, and the drug is more potent at blocking influenza B replication than the commonly used neuraminidase inhibitor oseltamivir. Naproxen exerted its antiviral activity by binding to the viral nucleoprotein (NP) and interfering with its export from the nuclei of infected cells. These findings and recent clinical trials suggest that the commonly used pain drug could be used as an anti-influenza agent in combination with other known influenza drugs.
