Virus World
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Virus World
Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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U.S. Health Officials Hope New COVID Vaccine Rules Can Ease Latest Surge | Reuters

U.S. Health Officials Hope New COVID Vaccine Rules Can Ease Latest Surge | Reuters | Virus World | Scoop.it

The Trump administration moved on Tuesday to accelerate vaccinations of Americans against COVID-19, releasing the rest of the doses it had been keeping in reserve and recommending states immediately open inoculations to those aged 65 and over.  Federal and state health officials have scrambled in recent days to step up vaccination programs that had given shots to only 9.3 million Americans as coronavirus infections remain at record highs in many U.S. states nearly two weeks into the new year. Many U.S. states had strict rules in place giving shots to healthcare workers and nursing home residents first, telling “non-essential workers” they might wait months for their turn. “We’ve already distributed more vaccine than we have healthcare workers and people in nursing homes,” U.S. Health and Human Services Secretary Alex Azar told ABC News. “We’ve got to get to more channels of administration.” Roughly 27.5 million doses have been distributed by the U.S. government to states so far, according to the U.S. Centers for Disease Control and Prevention.Azar said the outgoing administration, which had been keeping doses in reserve to make sure that all those who got a first inoculation receive their second shot on schedule, was now confident enough in the supply chain to release that stockpile. 

 

Last week, a spokesman for Joe Biden said the president-elect, who takes office on Jan. 20, would release more of the reserved doses. The pace of vaccinations has risen to 700,000 a day nationwide and was expected to hit 1 million a day within 10 days, officials said. “Michigan and states across the country remain ready to get more shots in arms, which is why the Trump Administration’s decision to grant our request and release millions of doses of the vaccine is so crucial,” Michigan Governor Gretchen Whitmer said in a statement. Whitmer, who had backed the lower vaccination age, is seeking permission from the U.S. government to purchase 100,000 vaccine doses directly from manufacturer Pfizer Inc.  The U.S. Food and Drug Administration has authorized the vaccine from Pfizer and partner BioNTech SE and a second vaccine from Moderna Inc for emergency use. As of Monday night, the United States had reported a total of 22.5 million coronavirus infections and 376,188 deaths during the pandemic, the most of any country. Nearly 130,000 Americans were hospitalized with COVID-19 at midnight on Monday.

 

GRIM SCENES AT CALIFORNIA HOSPITAL

A Reuters tally has shown that the number of COVID-19 patients requiring hospitalization may have leveled off, at least temporarily, although public health officials warn that further spread may still be seen from holiday gatherings. California Health and Human Services Secretary Dr. Mark Ghaly cited several promising trends in COVID metrics statewide in recent days, including a slowing in confirmed daily case numbers and a leveling off in positive tests. The number of new COVID hospitalizations statewide has fallen to about 2,500 admissions a day over the past two days from a daily average of about 3,500 admissions in previous days. Ghaly called that “the biggest signal to me that things are beginning to flatten and potentially improve."  Despite the encouraging statistics, staff at Providence St. Mary Medical Center in Apple Valley, California, said that the situation was grim. “Where in the beginning we were overloaded with a lot of patients - we still have a lot of patients - but now it seems like they’re sicker than they’ve ever been before,” said Mary Mendy, executive director of acute care services at the hospital some 90 miles northeast of Los Angeles.  “And every day there’s Code Blues on the floor and more and more patients are updated to ICU. It’s devastating,” Mendy said. The latest surge has potentially been compounded by a more infectious variant of the virus first seen in the UK and now found in at least 10 U.S. states - California, Florida, New York, Colorado, Georgia, Indiana, Connecticut, Minnesota, Pennsylvania and Texas.

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Model-Informed COVID-19 Vaccine Prioritization Strategies by Age and Serostatus | medRxiv

Model-Informed COVID-19 Vaccine Prioritization Strategies by Age and Serostatus | medRxiv | Virus World | Scoop.it

Limited initial supply of SARS-CoV-2 vaccine raises the question of how to prioritize available doses. Here, we used a mathematical model to compare five age-stratified prioritization strategies. A highly effective transmission-blocking vaccine prioritized to adults ages 20-49 years minimized cumulative incidence, but mortality and years of life lost were minimized in most scenarios when the vaccine was prioritized to adults over 60 years old. Use of individual-level serological tests to redirect doses to seronegative individuals improved the marginal impact of each dose while partially addressing existing inequities in COVID-19 impact. While maximum impact prioritization strategies were broadly consistent across countries, transmission rates, vaccination rollout speeds, and estimates of naturally acquired immunity, this framework can be used to compare impacts of prioritization strategies across contexts.

 

Available in medRxiv (Dec. 7, 2020):

 https://doi.org/10.1101/2020.09.08.20190629

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