Anti-citrullinated protein antibodies in RA are produced by circulating plasmablasts, renewed from memory B cell pool.
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Circulating plasmablasts/plasma cells as a source of anti-citrullinated protein antibodies in patients with rheumatoid arthritis. Kerkman PF, Rombouts Y, van der Voort EIH, Trouw LA, Huizinga TWJ, Toes REM, Scherer HU. Ann Rheum Dis 2013 Jul; 72:1259–1263.
The effect of targeted rheumatoid arthritis therapies on anti-citrullinated protein autoantibody levels and B cell responses. Modi S, Soejima M, Levesque MC. Clin Exp Immunol 2013 Jul; 173(1):8-17.
B effector cells in rheumatoid arthritis and experimental arthritis. Finnegan A, Ashaye S, Hamel KM. Autoimmunity 2012 Aug; 45(5):353-63.