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Scoop.it!
Anti-citrullinated protein antibodies in RA are produced by circulating plasmablasts, renewed from memory B cell pool. 
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Scoop.it!
Mesin L, Sollid LM and Di Niro R (2012) The intestinal B-cell response in celiac disease. Front. Immun. 3:313. doi: 10.3389/fimmu.2012.00313
The function of intestinal immunity is to provide protection toward pathogens while preserving the composition of the microflora and tolerance to orally fed nutrients. This is achieved via a number of tightly regulated mechanisms including production of IgA antibodies by intestinal plasma cells. Celiac disease is a common gut disorder caused by a dysfunctional immune regulation as signified, among other features, by a massive intestinal IgA autoantibody response. Here we review the current knowledge of this B-cell response and how it is induced, and we discuss key questions to be addressed in future research....
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Circulating plasmablasts/plasma cells as a source of anti-citrullinated protein antibodies in patients with rheumatoid arthritis. Kerkman PF, Rombouts Y, van der Voort EIH, Trouw LA, Huizinga TWJ, Toes REM, Scherer HU. Ann Rheum Dis 2013 Jul; 72:1259–1263.
The effect of targeted rheumatoid arthritis therapies on anti-citrullinated protein autoantibody levels and B cell responses. Modi S, Soejima M, Levesque MC. Clin Exp Immunol 2013 Jul; 173(1):8-17.
B effector cells in rheumatoid arthritis and experimental arthritis. Finnegan A, Ashaye S, Hamel KM. Autoimmunity 2012 Aug; 45(5):353-63.