Immunopathology & Immunotherapy
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Immunopathology & Immunotherapy
Latest advances in immunopathology diagnosis and treatment
Curated by Alfredo Corell
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Celiac Disease Autoimmunity - HLA susceptibility by haplotype and country - NEJM

Celiac Disease Autoimmunity - HLA susceptibility by haplotype and country - NEJM | Immunopathology & Immunotherapy | Scoop.it
I first came across the term “celiac disease autoimmunity” a few weeks ago as I read summaries of the article “Risk of Pediatric Celiac Disease According to HLA Haplotype and Country” that was published in the July 3, 2014 issue of the New England Journal of Medicine (NEJM).

Based on my re
Alfredo Corell's insight:

Liu E, Lee HS, Aronsson CA, et al. TEDDY Study Group. Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med. 2014 Jul 3;371(1):42-9.

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Celiac Disease and Autoimmunity: Review and Controversies

Celiac Disease and Autoimmunity: Review and Controversies | Immunopathology & Immunotherapy | Scoop.it
Gastroenterology Medical Article: Celiac Disease and Autoimmunity: Review and Controversies (Celiac Disease and Autoimmunity: Review and Controversies: Current Allergy and Asthma Reports http://t.co/EpTBXJQdva...
Alfredo Corell's insight:

dowload the complete pdf file : http://link.springer.com/content/pdf/10.1007%2Fs11882-013-0352-1.pdf

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Link Between Gluten and Immune Reaction Revealed for HLA-DQ8 Celiac Disease - The Sacramento Bee

Link Between Gluten and Immune Reaction Revealed for HLA-DQ8 Celiac Disease - The Sacramento Bee | Immunopathology & Immunotherapy | Scoop.it
/PRNewswire/ -- A link between gluten and the immune system has literally been visualized in new research published today in a leading scientific journal, Immunity.

 

The new at "The Sacramento Bee"

http://www.sacbee.com/2012/10/11/4902859/link-between-gluten-and-immune.html

 

The article at "Immunity" (Cell Press)

http://www.sciencedirect.com/science/article/pii/S1074761312004190

 

 

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KEY ADVANCES IN MEDICINE by Nature Reviews journals

KEY ADVANCES IN MEDICINE by Nature Reviews journals | Immunopathology & Immunotherapy | Scoop.it
Alfredo Corell's insight:

Including Immunology (pathology and therapies) topics:


  • 29 TYpE 2 DiAbETES MElliTUS | A central role of the gut in glucose homeostasis; Geltrude Mingrone and Lidia Castagneto-Gissey
  • 30 METAbOliSM | The gut microbiota manages host metabolism; Patrice D. Cani
  • 35 hEpATiTiS C | HCV causes systemic disorders that can be cured; Francesco Negro
  • 37 fAECAl MiCRObiOTA TRANSplANTATiON | Developing human gut microbiota as a class of therapeutics; Alexander Khoruts
  • 38 COEliAC DiSEASE | New insights in dietary-gluten-induced autoimmunity; Katri Kaukinen and Markku Mäki
  • 42 ibD | Enriching the therapeutic armamentarium for IBD;  Silvio Danese and Laurent Peyrin-Biroulet
  • 51 TRANSplANTATiON iMMUNOlOgY | New approaches to diagnosis of rejection; Nicholas A. Zwang and Laurence A. Turka
  • 65 MUlTiplE SClEROSiS | Novel triggers, treatment targets and brain atrophy measures; Xavier Montalban and Mar Tintoré
  • 71 SYSTEMiC lUpUS ERYThEMATOSUS | Taking a closer look at biologic therapy for SLE; David A. Isenberg and Anisur Rahman
  • 72 EpigENETiCS | DNA methylation and miRNA—key roles in systemic autoimmunity; Bruce C. Richardson and Dipak R. Patel
  • 74 RhEUMATOiD ARThRiTiS | Translational medicine in RA—time for change; Pierre Miossec


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Wheat for people allergic to gluten: Possible?

Wheat for people allergic to gluten: Possible? | Immunopathology & Immunotherapy | Scoop.it

The news at "Los Angeles Times":

http://touch.latimes.com/#section/-1/article/p2p-73429290/

 

The original publication at PNAS:

http://www.pnas.org/content/early/2012/11/21/1217927109

 

What to know about celiac disease, gluten sensitivity, and gluten-free diets:

http://www.webmd.com/digestive-disorders/celiac-disease/features/gluten-intolerance-against-grain

 

Gluten-free diet slideshow:

http://www.webmd.com/diet/ss/slideshow-gluten-free-diet

 

Celiac Disease Symtoms:

http://www.webmd.com/digestive-disorders/celiac-disease/celiac-disease-symptoms

 

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The intestinal B-cell response in celiac disease | Frontiers in Mucosal Immunity

The intestinal B-cell response in celiac disease | Frontiers in Mucosal Immunity | Immunopathology & Immunotherapy | Scoop.it

Mesin L, Sollid LM and Di Niro R (2012) The intestinal B-cell response in celiac disease. Front. Immun. 3:313. doi: 10.3389/fimmu.2012.00313

 

The function of intestinal immunity is to provide protection toward pathogens while preserving the composition of the microflora and tolerance to orally fed nutrients. This is achieved via a number of tightly regulated mechanisms including production of IgA antibodies by intestinal plasma cells. Celiac disease is a common gut disorder caused by a dysfunctional immune regulation as signified, among other features, by a massive intestinal IgA autoantibody response. Here we review the current knowledge of this B-cell response and how it is induced, and we discuss key questions to be addressed in future research....

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