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Genes that sculpt the immune system were transformed by exposure in many First Peoples By Michael Price Nov. 15, 2016 , 1:30 PM
For example, a variant of a gene known as a HLA-DQA1, which codes for proteins that sort healthy cells from invading viruses and bacteria, was found in nearly 100% of ancient individuals, but in only 36% of modern ones. 
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Cigarette smoke contains free radicals and an have adverse effect to the immune system.
Alfredo Corell's insight:
by Zakiah Jubri, Azian Abdul Latif, Abdul Gapor Top and Wan Zurinah Ngah Nutrition Journal 2013, 12:2 doi:10.1186/1475-2891-12-2 Published: 3 January 2013 Link to the provisional pdf: http://www.nutritionj.com/content/pdf/1475-2891-12-2.pdf ;
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The immune system is a complex structure, built over a person’s life in response to environmental conditions. Antibodies, proteins that tag and attack viruses and bacteria, “remember” past invaders, allowing white blood cells to quickly respond during subsequent infections. Because different groups of people encounter different diseases—the European settlers had high exposure to smallpox, measles, and influenza thanks to close contact with livestock—they develop different antibodies. But what about the genes behind the immune system? Could those also change vulnerability to certain diseases?