Get Started for FREE
Sign up with Facebook Sign up with X
I don't have a Facebook or a X account
 Your new post is loading...
Your new post is loading...
Scoop.it!
Un equipo del Centro Nacional de Investigaciones Oncológicas (CNIO) han descubierto dos posibles vías de tratamiento de la psoriasis basadas en compuestos farmacológicos que ya existen pero que no se habían contemplado hasta el momento, que en los... 
No comment yet.
Sign up to comment
Scoop.it!
RT @TeamMEDiary: CD8+ T-Cell Deficiency, Epstein-Barr Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis
Alfredo Corell's insight:
Autoimmune Dis. 2012; 2012: 189096. Published online 2012 January 24. doi: 10.1155/2012/189096PMCID: PMC3270541CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying HypothesisMichael P. Pender ConclusionsCD8+ T-cell deficiency is a general feature of chronic autoimmune diseases and also occurs in healthy blood relatives of patients with these diseases. It is proposed that this deficiency is genetically determined and underlies the development of chronic autoimmune diseases by impairing CD8+ T-cell control of EBV infection, with the result that EBV-infected autoreactive B cells accumulate in the target organ where they produce pathogenic autoantibodies and provide costimulatory survival signals to autoreactive T cells. Autoimmunity is postulated to evolve in a series of steps culminating in the development of ectopic lymphoid follicles containing EBV-infected autoreactive B cells in the target organ. It is also proposed that deprivation of sunlight and vitamin D facilitates the development of autoimmune diseases by aggravating the CD8+ T cell deficiency and thereby further impairing control of EBV. The hypothesis makes predictions which can be tested, including the prevention and successful treatment of chronic autoimmune diseases by controlling EBV infection.
Scoop.it!
Alfredo Corell's insight:
A guide for parents who recieve an abnormal screen for SCID.
And the Newborn Screening Campaign, that in the near future will have the first sucess in Pennsylvania.
|
Scoop.it!
Nueva edición de la obra de referencia en Medicina Interna en español, dirigida por el profesor Rozman y co-dirigida por el profesor Cardellach, cuenta con la colaboración de 400 expertos en cada área, que pertenecen a las principales facultades y hospitales de España, Latinoamérica y otros países.
Scoop.it!
To raise vaccination rates, some states have made it much harder for parents to get exemptions for their children from immunizations based on personal beliefs. One doctor says restrictions could backfire.
Alfredo Corell's insight:
But Dr. Edgar Marcuse, a pediatrician at Seattle Children's Hospital, says that strategy is likely to backfire. He's trying to come up with new ways to balance parents' freedom of choice with public health needs. He described the problem in the latest issue of the Archives of Adolescent and Pediatric Medicine.
Scoop.it!
Elimination of Germinal Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen Immunity, 08 November 2012 Authors Tyani D. Chan, Katherine Wood, Jana R. Hermes, Danyal Butt, Christopher J. Jolly, Antony Basten, Robert Brink
Summary Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B cells has long been recognized, it has not previously been possible to identify such cells and study their fate. In the current study, self-reactive B cells generated de novo in the GC failed to survive when their target self-antigen was either expressed ubiquitously or specifically in cells proximal to the GC microenvironment. By contrast, GC B cells that recognized rare or tissue-specific self-antigens were not eliminated, and could instead undergo positive selection by cross-reactive foreign antigen and produce plasma cells secreting high-affinity autoantibodies. These findings demonstrate the incomplete nature of GC self-tolerance and may explain the frequent association of cross-reactive, organ-specific autoantibodies with postinfectious autoimmune disease.
A summary in Garvan Institute: http://www.garvan.org.au/news-events/news/how-infection-can-trigger-autoimmune-disease.html
A previous publication of this theory: Mechanisms for the induction of autoimmunity by infectious agents Kai W. Wucherpfennig Published in Volume 108, Issue 8 (October 15, 2001)
http://www.jci.org/articles/view/14235
|
La noticia en ABC salud: http://www.abc.es/salud/noticias/20140227/abci-psoriasis-cnio-201402261329.html
En uno de los trabajos, publicado en «Immunity», se demuestra que los síntomas de la enfermedad desaparecen cuando se bloquea una proteína llamada S100A9. En el otro artículo, que aparece en «Science Translational Medicine», se demuestra que esto también sucede si se actúa sobre un ARN no codificante, el micro ARN miR-21.