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Jennifer W. Leiding, MD,Steven M. Holland, MD
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
Received 23 March 2012; received in revised form 6 June 2012; accepted 25 July 2012. published online 02 October 2012.
Infection with human papillomavirus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy. It is also an underappreciated manifestation of primary immunodeficiency. Mutations in EVER1, EVER2, GATA2, CXCR4, and dedicator of cytokinesis 8 (DOCK8) are typically associated with extensive HPV infections, whereas several other primary immune defects result in severe HPV much less frequently. We review immunodeficiencies with severe HPV infections and the mechanisms underlying them.
pdf article: http://download.journals.elsevierhealth.com/pdfs/journals/0091-6749/PIIS0091674912012973.pdf
