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Rheumatoid arthritis (RA) is an autoimmune disorder in which immune cells attack the joints, causing inflammation, swelling, and erosion. Specific sets of immune cells, known as T cells, are responsible for inducing disease. In this issue of the Journal of Clinical Investigation, researchers led by Harvey Cantor at Harvard University analyzed the contributions of different subsets of T cells to an RA-like condition in mice. 
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The NPC became part of NICE in April 2011.
During this transition period some change has been necessary to best align the work of the NPC with the NICE portfolio. This has included, revising the production processes for the development of future outputs so that they are easily identifiable as NICE products and also continue to be recognised and valued by our existing audience.
From 15th May 2012, the team delivering the work of the NPC will form the NICE Medicines and Prescribing Centre and will sit alongside the Clinical Guidelines team within the Centre for Clinical Practice. The primary objective of the Medicines and Prescribing Centre will continue to be the provision of support for those using medicines across the NHS, including information on medicines, prescribing advice, training and education, governance and decision-making. All future Medicines and prescribing outputs will be published on the NICE website and signposted from the Medicines and prescribing homepage.
Although no new Medicines and prescribing content will be published to the NPC legacy website, the extensive catalogue of existing publications, resources and e-learning materials will still be available to view and download for as long as the information contained within them remains accurate and up-to-date. Feedback and enquiries can be sent to nice@nice.org.uk
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A summary in the news:
http://www.news-medical.net/news/20130211/CD82b-Tregs-can-remove-pathogenic-T-cell-subsets-and-inhibit-progression-of-RA.aspx
The complete article:
J Clin Invest. doi:10.1172/JCI66938.Copyright © 2013, The American Society for Clinical Investigation.Research ArticleAmelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells
Jianmei W. Leavenworth1,2, Xiaolei Tang1,2, Hye-Jung Kim1,2, Xiaoyang Wang1,2,3,4 and Harvey Cantor1,2