Immunopathology & Immunotherapy

Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy in which the patient’s own T cells are isolated in the laboratory, redirected with a synthetic receptor to recognize a particular antigen or protein, and reinfused into the patient. Clinical trials of CAR T cells directed to the CD19 antigen have shown impressive results in advanced B-cell malignancies at multiple academic centers over the last 3 years. We describe the technology of CAR T cells, findings at 5 academic centers, and toxicities associated with CAR T cell-treatment and their management. Although CAR T cells for B-cell malignancies are the most advanced in terms of clinical testing, CAR T cells are the basis of a new platform technology that is poised to be expanded to other hematologic and nonhematologic malignancies, especially as new targets are identified and manufacturing processes are streamlined.
  - See more at: http://www.onclive.com/publications/contemporary-oncology/2014/August-2014/Chimeric-Antigen-Receptor-CAR-T-Cell-Immunotherapy-for-Leukemia-and-Beyond?__scoop_post=3c482f60-3053-11e4-b39b-842b2b775358&__scoop_topic=827181#__scoop_post=3c482f60-3053-11e4-b39b-842b2b775358&__scoop_topic=827181

Link to Video-Lecture: http://www.youtube.com/watch?v=1sA_oz_1P5E 

Annu Rev Med. 2013 Nov 20. Chimeric Antigen Receptor Therapy for Cancer.Barrett DM, Singh N, Porter DL, Grupp SA, June CH.Review in Advance first posted online on November 20, 2013. (Changes may still occur before final publication print.)DOI: 10.1146/annurev-med-060512-150254 direct link to the Journal:http://www.annualreviews.org/doi/pdf/10.1146/annurev-med-060512-150254

• Mandy L. Ford,
• Andrew B. Adams
• & Thomas C. Pearson

Nature Reviews Nephrology 10, 14-24 (2014)  doi:10.1038/nrneph.2013.183

Ultimately, understanding the interplay between individual co-stimulatory and co-inhibitory pathways engaged during T-cell activation and
differentiation will lead to rational and targeted therapeutic interventions to manipulate T-cell responses and improve clinical outcomes.