Immunopathology & Immunotherapy

OBJETIVOS:
Reciclaje y actualización de profesionales de la inmunología clínica en el campo de los trasplantes.
•    Repasar las pruebas diagnósticas inmunológicas para el Diagnóstico y Seguimiento de diferentes tipos de Trasplantes (de órganos sólidos y hematopoyéticos).
•    Conocer las presentaciones clínicas de las patologías de más frecuentes asociadas a los trasplantes de órganos.
•    Entender la correlación de las manifestaciones clínicas con las pruebas analíticas en trasplantes.
•    Ser capaces de emitir un informe diagnóstico de calidad, preciso y entendible para los clínicos.
•    Ser capaces de proponer posibles Inmunoterapias de algunas situaciones pre- y post-trasplante estudiadas.

My personal collection of Educationsl Immunology, Immunopathology and Immunotherapy at Pinterest... is growing in a daily bases. Suggestions are wellcomed.

Paolo Sfrisoa, , ,Francesco Casoa,Sofia Tognonb,Paola Galozzia,Alessandra Gavaa,Leonardo Punzia

a Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italyb Ophthalmology Unit, Department of Neurosciences, University of Padova, Padova, Italy

http://dx.doi.org/10.1016/j.autrev.2012.07.028,

 

Blau syndrome (BS) is a rare autosomal dominant, autoinflammatory syndrome characterized by the clinical triad of granulomatous recurrent uveitis, dermatitis and symmetric arthritis. The gene responsible for BS has been identified in the caspase recruitment domain gene CARD15/NOD2. In the majority of patients, the disease is characterized by early onset, usually before 3–4 years of age. The manifestations at disease onset are usually represented by articular and cutaneous involvement signs, generally followed later by ocular manifestations which are often the most relevant morbidity of BS. In some cases the presence of fever is also observed; atypical cases of BS have been reported with cardiovascular, neurological, renal, intestinal and other organ involvement. The rarity and the variations in the severity and evolution of its expressions do not permit sufficient data about optimal treatment for patients with BS. The first step of therapy is represented by the use of corticosteroids and successively, in case of unsatisfactory response, by additional treatment with immunosuppressive agents. The results with biologic anti-cytokine agents, such as anti-TNFα and anti-IL1β, are different, particularly with regard to ocular morbidity. Clinical and genetic aspects of the familial and the sporadic form of BS will be discussed and focused on. A description of a case study of an Italian family is also included.

Blau syndrome, clinical and genetic aspects http://t.co/BALw5P69...

Images in Clinical Medicine from The New England Journal of Medicine — Disfiguring Angioedema

A 54-year-old woman presented to our clinic with progressive swelling of her face. (Panel A shows the patient's face without swelling and Panels B through D show two different episodes of swelling,

Via Gilbert C FAURE

After one year, studies published in the Journal of Allergy and Clinical Immunology are available free of charge.

Via Gilbert C FAURE