Immunopathology & Immunotherapy
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Immunopathology & Immunotherapy
Latest advances in immunopathology diagnosis and treatment
Curated by Alfredo Corell
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KEY ADVANCES IN MEDICINE by Nature Reviews journals

KEY ADVANCES IN MEDICINE by Nature Reviews journals | Immunopathology & Immunotherapy | Scoop.it
Alfredo Corell's insight:

Including Immunology (pathology and therapies) topics:


  • 29 TYpE 2 DiAbETES MElliTUS | A central role of the gut in glucose homeostasis; Geltrude Mingrone and Lidia Castagneto-Gissey
  • 30 METAbOliSM | The gut microbiota manages host metabolism; Patrice D. Cani
  • 35 hEpATiTiS C | HCV causes systemic disorders that can be cured; Francesco Negro
  • 37 fAECAl MiCRObiOTA TRANSplANTATiON | Developing human gut microbiota as a class of therapeutics; Alexander Khoruts
  • 38 COEliAC DiSEASE | New insights in dietary-gluten-induced autoimmunity; Katri Kaukinen and Markku Mäki
  • 42 ibD | Enriching the therapeutic armamentarium for IBD;  Silvio Danese and Laurent Peyrin-Biroulet
  • 51 TRANSplANTATiON iMMUNOlOgY | New approaches to diagnosis of rejection; Nicholas A. Zwang and Laurence A. Turka
  • 65 MUlTiplE SClEROSiS | Novel triggers, treatment targets and brain atrophy measures; Xavier Montalban and Mar Tintoré
  • 71 SYSTEMiC lUpUS ERYThEMATOSUS | Taking a closer look at biologic therapy for SLE; David A. Isenberg and Anisur Rahman
  • 72 EpigENETiCS | DNA methylation and miRNA—key roles in systemic autoimmunity; Bruce C. Richardson and Dipak R. Patel
  • 74 RhEUMATOiD ARThRiTiS | Translational medicine in RA—time for change; Pierre Miossec


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Cellular Immunology - Th17 cells in type 1 diabetes

Cellular Immunology - Th17 cells in type 1 diabetes | Immunopathology & Immunotherapy | Scoop.it
Cellular Immunology

Volume 280, Issue 1, November 2012, Pages 16–21

Shiying Shaoa, 1,Fan Heb, 1,Yan Yanga,Gang Yuana,Muxun Zhanga,Xuefeng Yua, , a Division of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, PR Chinab Division of Nephrology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, PR Chinahttp://dx.doi.org/10.1016/j.cellimm.2012.11.001,
Alfredo Corell's insight:

► This review firstly summarizes Th17 mediated immunology mechanism for T1D. ► We thoroughly introduce the characteristics of Th17 cells. ► Better understanding of mechanisms helps to develop treatment strategies for T1D.

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Immune protein CD52 could stop diabetes in its tracks

Immune protein CD52 could stop diabetes in its tracks | Immunopathology & Immunotherapy | Scoop.it
Immune protein could stop diabetes in its tracks
Alfredo Corell's insight:

Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed.

 

video by Prof. Len Harrison (Walter+Eliza Hall) http://www.youtube.com/watch?feature=player_embedded&v=IwtphdQL6co

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People With Severe Psoriasis at Twice the Risk of New-Onset Diabetes - Archives of Dermatology

People With Severe Psoriasis at Twice the Risk of New-Onset Diabetes - Archives of Dermatology | Immunopathology & Immunotherapy | Scoop.it

Increased Risk of Diabetes Mellitus and Likelihood of Receiving Diabetes Mellitus Treatment in Patients With Psoriasis

Rahat S. Azfar, MD; Nicole M. Seminara, MD; Daniel B. Shin, BA; Andrea B. Troxel, ScD; David J. Margolis, MD, PhD; Joel M. Gelfand, MD, MSCE

Arch Dermatol. 2012;148(9):995. doi:10.1001/archdermatol.2012.1401

 

Objective To assess the risk of incident diabetes mellitus (DM) in patients with psoriasis and to evaluate DM treatment patterns among patients with psoriasis and incident DM.

Design Population-based cohort study.

Setting United Kingdom–based electronic medical records.

Patients We matched 108 132 patients with psoriasis aged 18 to 90 years with 430 716 unexposed patients based on practice and time of visit. For our nested study, only patients who developed incident DM during our study time were included.

Main Outcome Measures Incident DM and adjusted risk of pharmacotherapy among those with incident DM.

Results The fully adjusted hazard ratios (95% CIs) for incident DM were 1.14 (95% CI, 1.10-1.18), 1.11 (95% CI, 1.07-1.15), and 1.46 (95% CI, 1.30-1.65) in the overall, mild, and severe psoriasis groups, respectively. Among those with incident DM and severe psoriasis, the adjusted risk for receiving DM pharmacotherapy was 1.55 (95% CI, 1.15-2.10).

Conclusions Our results suggest that psoriasis is an independent risk factor for the development of type 2 DM in a dose-dependent manner, and that patients with severe psoriasis who develop DM are more likely to receive systemic diabetic therapies in comparison with patients with DM but without psoriasis.

 

The finding in the news:

http://www.webmd.com/skin-problems-and-treatments/psoriasis/news/20120829/psoriasis-linked-diabetes

 

http://www.emaxhealth.com/1275/psoriasis-and-type-2-diabetes-whats-connection

 

In spanish:

http://www.elmundo.es/elmundosalud/2012/10/23/pielsana/1351013633.html

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