Largest Microbiome Study on Newly Diagnosed Patients Gives Insight Into Crohn's Disease and Shows Antibiotic Treatment May Worsen Disease
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Immunopathology & Immunotherapy
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Latest advances in immunopathology diagnosis and treatment
Curated by
Alfredo Corell
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Liver Disease Diagnostics: Antibody-Based Diagnosis of Autoimmune Liver Disease For the launch of our Liver-9-Line immunoblot test (to our press release “Liver Disease Diagnostics by Immunoblot” of May 16, 2011), I dug through a pile of literature... 
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Common variable immunodeficiency (CVID) (also known as Acquired hypogammaglobulinemia) is a group of approximately 150 primary immunodeficiencies (PIDs), whi...
Alfredo Corell's insight:
Documentary for all people. Short and easy to understand
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Leukemia is one of the leading journals in hematology and oncology. It is published monthly and covers all aspects of the research and treatment of leukemia and allied diseases.
Alfredo Corell's insight:
It is a european consortium working in an useful and important homogeneization protocols for diagnosis of haematologic malignancies in Europe. The history starts fabulous. Then, when your read the papers and see that some very popular and good flow cytometers aren't there (as the Galios, for example), and when you see also an important byass in the recomended providers for fluorescent monoclonals... it doesn't seem so fabulous.
Alfredo Corell's curator insight,
January 7, 2013 7:05 AM
It is a european consortium working in an useful and important homogeneization protocols for diagnosis of haematologic malignancies in Europe. The history stars fabulous. Then, when your read the papers and see that some very popular and good flow cytometers aren't there (as the Galios, for example), and when you see also an important byass in the recomended providers for fluorescent monoclonals... it doesn't seem so fabulous.
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Alfredo Corell's insight:
A guide for parents who recieve an abnormal screen for SCID.
And the Newborn Screening Campaign, that in the near future will have the first sucess in Pennsylvania.
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Alfredo Corell's insight:
You can find very good material at his page:
A simple review of the Immune Systems (for kids and families): http://www.info4pi.org/aboutPI/index.cfm?section=aboutPI&content=nurseposter&CFID=1110688&CFTOKEN=51588866
The 10 warning sings of these diseases http://www.info4pi.org/aboutPI/index.cfm?section=aboutPI&content=warningsigns
The key to find expert: http://www.info4pi.org/expertlocator/index.cfm?section=expertlocator
The 4 stages of immunology testing: http://www.info4pi.org/aboutPI/index.cfm?section=aboutPI&content=algorithm
and a huge amount of links and publications for Patients as well as Professionals.
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Protocolos de Inmunología Clínica y Alergología | AEP - Clinical Immunology and Alergology Protocols
Capítulos: 1. Actitud a seguir ante una sospecha de alergia a fármacos 2. Actitud ante el niño afecto de dermatitis atópica 3. Actitud ante el niño con urticaria-angioedema y anafilaxilia 4. Alergia a huevo en el niño 5. Alergia a proteínas de leche de vaca 6. Clínica general de las enfermedades alérgicas en el niño 7. Diagnóstico de las inmunodeficiencias primarias 8. Educación del paciente alérgico: prevención de riesgos y tratamiento 9. Farmacoterapia de las enfermedades alérgicas 10. Historia clínica en alergia infantil 11. Hipersensibilidad a veneno de himenópteros 12. Inmunoterapia: mecanismos de acción, indicaciones y beneficios 13. La marcha alérgica 14. Manejo del niño con sospecha de alergia de alimentos 15. Métodos diagnósticos en alergia. Técnicas in vivo e in vitro Protocolos diagnósticos en asma bronquial Protocolos terapéuticos en el asma infantil
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Images in Clinical Medicine from The New England Journal of Medicine — Disfiguring Angioedema A 54-year-old woman presented to our clinic with progressive swelling of her face. (Panel A shows the patient's face without swelling and Panels B through D show two different episodes of swelling, Via Gilbert C FAURE
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Neutrophils are essential components of the haematopoietic and immune system, and quantitative or qualitative abnormalities of neutrophils can result in life-threatening infection. Neutropenia is a low neutrophil count and results from decreased production, accelerated utilisation, increased destruction, or a shift in compartments. A combination of these mechanisms may be present. Causes can be congenital or acquired. The most serious complication of neutropenia is infection, which can be fatal. The source is usually endogenous flora of the gut and mucosa (commonly Staphylococcus and gram-negative organisms). Fungal infections occur with increased frequency, but there is no increased risk of viral or parasitic infection. Common sites of infection include mucous membranes (gingivitis, stomatitis, perirectal abscesses), skin (cellulitis), and lungs (pneumonia).
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Catálogo de pruebas (volver) Recogida de muestras (volver) Cómo remitir las muestras
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Scope and Target Population:
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The Blog on Autoimmunity, Autoimmune Diseases, and Autoimmune Diagnostics by Orgentec (a reactive provider) but still a very good autoimmunity blog.
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Fluorescence Image Library at University of Birmingham and Clinical Association with ANA
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Press release about a research to be presented in the American Academy of Neurology 66th Annual Meeting. Better be cautious and patient with this information: in the study only 16 patients vs 16 healthy controls have been studied. A too small cohort to make a strong conclusion.
Alfredo Corell's insight:
PHILADELPHIA – An antibody found in the blood of people with multiple sclerosis (MS) may be present long before the onset of the disease and its symptoms, according to a study released today that will be presented at theAmerican Academy of Neurology’s 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.
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Alfredo Corell's curator insight,
June 30, 2013 2:24 PM
The literature on diagnostic tests for food allergy currently lacks clear consensus regarding the accuracy and safety of different investigative approaches. The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management, and impact on quality of life, which will be used to inform the formulation of clinical recommendations. The aim of this systematic review will be to assess the diagnostic accuracy of tests aimed at supporting the clinical diagnosis of IgE-mediated food allergy.
link to the provisional pdf: http://www.ctajournal.com/content/pdf/2045-7022-3-18.pdf
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ALLERGY Review Article You have free access to this contentSchnitzler's syndrome: diagnosis, treatment, and follow-upA. Simon1,B. Asli2,M. Braun-Falco3,H. De Koning4,J.-P. Fermand2,C. Grattan5,K. Krause6,H. Lachmann7,C. Lenormand8,V. Martinez-Taboada9,M. Maurer6,M. Peters10,R. Rizzi11,F. Rongioletti12,T. Ruzicka3,L. Schnitzler13,B. Schubert14,J. Sibilia15,D. Lipsker8 Article first published online: 9 MAR 2013 DOI: 10.1111/all.12129
Alfredo Corell's insight:
Schnitzler's syndrome is characterized by recurrent urticarial rash and monoclonal gammopathy, associated with clinical and biological signs of inflammation and a long-term risk of AA amyloidosis and overt lymphoproliferation.
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Severe combined immunodeficiency (SCID) is an immune deficiency that can be successfully treated if it's identified early.
Alfredo Corell's insight:
Principles and basis to explain falimies and kids abou these rare disease. Worth a reading for any student of Medicine or Nurses themselves.
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For any questioun, doubt, english documents or enqueries: .
DIAGNOSTIC TESTS FOR: -Ophtalmic infections -Ophtalmic inflammation -Ophtalmic diseases genetics, -Immune-mediated ocular inflammation Laboratorio de Inmunología (inmunoLAB) Via Alfredo Corell
Alfredo Corell's insight:
Feel free of asking any question or make any suggestion.
Alfredo Corell's curator insight,
September 8, 2013 11:34 AM
Any sample (biopsies, brush or impresion cytologies, corneal scraping, vitreous or aqueus humour, ....) DIAGNOSTIC TESTS FOR:
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Systemic reactions from allergy skin testing: 0.4% for skin prick testing, 3.2% for intradermal Skin testing is the diagnostic cornerstone for allergies and is considered extremely safe, carrying only a small risk of systemic reactions. A prospective study included 1,500 patients at the University of South Florida and aimed to determine the 12-month incidence of systemic reactions (SRs) to skin prick testing (SPT) and intradermal skin testing (ST). Epinephrine (0.2 mL of a 1:1,000 dilution) was administered intramuscularly in the deltoid as soon as any remote signs or symptoms occurred.
Yotam Levin's curator insight,
August 2, 2015 12:53 PM
Interesting data for allergists to consider..
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New test to help reduce diagnosis time for TBTimes of IndiaGenexpert has been installed in the microbiology department of Madurai Medical College.
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Alberto Martini, Dipartimento di Pediatria, Università di Genova, Pediatria II e Reumatologia, Istituto G Gaslini, Genova, Italy http://dx.doi.org/10.1016/j.autrev.2012.07.022,
Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in the pathogenesis is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long term prognosis.
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German researchers have identified an antibody that is found in the blood of nearly half of all multiple sclerosis patients, and may be a new biomarker for MS.
NEJM artícule: http://www.nejm.org/doi/full/10.1056/NEJMe1204118 news at Health Daily: http://health.usnews.com/health-news/news/articles/2012/07/11/scientists-pinpoint-antibody-that-may-be-specific-to-ms-patients
Via Gilbert C FAURE
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The Canadian Society of Allergy and Clinical Immunology (CSACI) is very concerned about the increased marketing of food-specific immunoglobulin G (IgG) testing towards the general public over the past few years, supposedly as a simple means by which to identify “food sensitivity”, food intolerance or food allergies. In the past, this unvalidated form of testing was usually offered by alternative or complementary health providers, but has now become more widely available with direct-to-consumer marketing through a nationwide chain of pharmacies.
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immunodeficiency database... De un modo muy intuitivo ayuda en el diagnóstico de las Inmunodeficiencias Primarias y remite a laboratorios de referencia (principalmente americanos) para su diagnóstico.
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For people with autoimmune diseases, getting a proper diagnosis can be one of the most difficult challenges they face. The American Autoimmune Related Diseases Association (AARDA) conducted a survey of autoimmune disease patients and found that the majority of those eventually diagnosed with serious autoimmune diseases had significant problems in getting a correct diagnosis. Many were incorrectly diagnosed with a variety of conditions that have no specific blood test to confirm the diagnosis. Many were told that their symptoms were in their heads or that they were under too much stress. Further, the survey revealed that 45 percent of autoimmune disease patients had been labeled hypochondriacs in the earliest stages of their illnesses.
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Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD), are genetically linked to host pathways that implicate an underlying role for aberrant immune responses to intestinal microbiota. However, patterns of gut microbiome dysbiosis in IBD patients are inconsistent among published studies. Using samples from multiple gastrointestinal locations collected prior to treatment in new-onset cases, we studied the microbiome in the largest pediatric CD cohort to date. An axis defined by an increased abundance in bacteria which include Enterobacteriaceae, Pasteurellacaea, Veillonellaceae, and Fusobacteriaceae, and decreased abundance in Erysipelotrichales, Bacteroidales, and Clostridiales, correlates strongly with disease status. Microbiome comparison between CD patients with and without antibiotic exposure indicates that antibiotic use amplifies the microbial dysbiosis associated with CD. Comparing the microbial signatures between the ileum, the rectum, and fecal samples indicates that at this early stage of disease, assessing the rectal mucosal-associated microbiome offers unique potential for convenient and early diagnosis of CD.
Divulgative news: http://www.sys-con.com/node/3009818